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I did that with the USERS folder as soon as I got my current machine. Programs get installed on the C: drive (SSD) for fast loading, but saves etc. automatically go to D: (regular HDD)

Games that insist on putting everything - code and data - in one folder, get installed to D;/Games, so that the protection of the Program Files folder doesn't cause pain. Newer games are less likely to do so, but having a separate Games folder also helps when upgrading, as you can often just copy that folder across to the new hardware.